Prenata Preserver tubes
For collection and stabilization of whole blood for circulating cell free DNA (ccfDNA) applications
The importance of blood collection methods in cell-free DNA applications
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​The introduction of non-invasive methods like liquid biopsy that use cell-free DNA (cfDNA) for molecular diagnostics has been of growing interest in oncology. DNA from whole blood can provide valuable genomic information for healthcare professionals without the need for tissue biopsies.
Whilst taking a blood sample is a simple procedure, if blood plasma is not preserved or isolated within 24 hours of blood draw, the degradation of nucleated white blood cells will cause the release of intracellular genomic DNA (gDNA) into the plasma. This can contaminate the cfDNA fraction affecting the reliability and validity of data. This time constraint means that any delays in transport of samples from collection site to analysis location can negatively impact on results.
Our Prenata Preserver, blood collection tubes are an easy-to-use, direct-draw blood collection method that maintain white blood cell integrity for up to 14 days. They provide an alternative to EDTA tubes that help ensure collection of contamination-free cfDNA.
Stability during transit
Stabilizes whole blood for up to 14 days post blood draw for batching samples for countrywide or international shipping.
Common applications validated
Preserves high quality cell-free DNA for use in downstream techniques such as qPCR, dPCR, NGS and applications such as NIPT, liquid biopsy and transplantation monitoring.
Plastic evacuated tube
Plastic tube rather than glass prevents unwanted sample loss and hazardous breakages. Standard tube format enables routine blood draws.
Clinical lab ready
Automation system and LIMS system ready, suitable for high throughput automation such as Hamilton Star. Included barcode assists with LIMS.
Technical Performance
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Maximize cfDNA yield
Blood is collected into Prenata Preserver tubes which contain an additive to simultaneously stabilize blood cells and impede coagulation. The stabilizer preserves white / nucleated blood cells, preventing lysis and the release of intracellular gDNA into the plasma which would otherwise dilute and contaminate the cell-free DNA fraction.
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This ensures cfDNA yields are optimised and remain stable for up to 14 days until processing and analysis can be performed.
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Avoiding contaminating gDNA is critical for ensuring optimal sequencing of cfDNA and maintaining sensitivity of your assays.
Figure 1. Yield: Prenata Preserver vs Market leader
cfDNA yield [ng per 1ml of plasma] for Prenata Preserver tubes compared to Competitor S, 10 days post blood draw.
Figure 2. Sample stability: Yield
Stability of cfDNA yield [ng per 1ml of plasma]. Sample stability was evaluated using 3 different donors across 10 days, where total yields were shown consistent between the time points.
​​​Ordering Information​
Part Number Description
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PRE-PRE-10 Prenata Preserver tubes, 10 pack
PRE-PRE-50 Prenata Preserver tubes, 50 pack
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