PrenaSeq Analysis Software
Analyse lpWGS of cfDNA for Prenatal Analysis
PrenaSeq is a secure cloud-based analysis software for analysis and detection of Prenatal aberrations including Trisomy, 21, 18, 13, Sex Chromosome Aneuploidies (SCA), rare autosomal aneuploidies and microdeletions. The software has been developed within an ISO13485 manufacturing procedure and is housed and delivered under ISO27001 data security infrastructure.
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PrenaSeq offers an improved method of fetal fraction calculation which we believe offers a more sensitive test and the ability to reduce the number of incorrect results (especially false positives) seen by other prenatal analysis software.
PrenaSeq proprietary algorithms are designed to work with low-pass Whole Genome Sequencing (WGS), NGS data generated from either Illumina (NextSeq550 or NextSeq2000) or Element Bioscience (AVITI, AVITI 24) Sequencers.
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The inputs are fastq files from either Illumina or Element Bioscience sequencers which can be directly setup to output data into your dedicated, secure account and the output is .json files which can either be directly linked to a customers laboratory information management system (LIMS) or using the PrenSeq software you can visualise and report on each sample processed through and create a per sample report.
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PrenaSeq software is a research use only tool which should only be used by a clinical lab as a Laboratory Developed Test and only then upon full validation within your laboratory.​​​
Secure and scalable
Secure, cloud based analysis platform. Enables small to high throughput analysis in a secure, cost effective and rapid manner
Comprehensive analysis
Enables comprehensive chromosomal and sub-chromosomal analysis and resolution. Comprehensive aberration analysis and reporting including Trisomy 21,18,13, SCA, rare autosomal aneuploidies and microdeletion syndromes
Connection-ready software
Connect your sequencer directly to your analysis account within our analysis software or connect the sequencer output folder. Our software will the automatically analyse the data and generate a .json format report which can be connected via an API to your LIMS system
Simple user interface with customisable reporting
Intuitive cloud based user interface enables customised reporting including selecting relevant reporting fields, saving reporting templates, review of results and QC to date and printing or saving of reports
Technical Performance
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Comparison to available software
In order to test and evaluate the performance of the PrenaSeq software we decided to benchmark the software and its analysis to Illumina VeriSeq V2 software. VeriSeq V2 software is available to customers who buy products and software as a combined solution. Working with an accredited laboratory we obtained blinded NGS data (fastq) from 1,716 samples that had been processed through the VeriSeq V2 solution and reported already.
We analysed the samples across the PrenaSeq NIPT analysis software (Illumina version) to understand concordance between our method and a popular commercial alternative.
Figure 1.
1,716 samples were processed across the Illumina VeriSeq NIPT solution v2 by a clinically accredited lab provider, data was blind-shared with Prenata and analysed for concordance analysis
Figure 2. Concordance of analysis methods
Review of concordance between VeriSeq v2 reported results vs PrenaSeq (Illumina version) results from 1,716 samples and for the common aneuploidies
​​​Ordering Information​
Part Number Description
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ANA-SOF-001 PrenaSeq Analysis Software, 96 report credits
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